Table 1 Genomic features associated with the Wisconsin outbreak isolates*.

From: Evolutionary dynamics and genomic features of the Elizabethkingia anophelis 2015 to 2016 Wisconsin outbreak strain

Name

Start

End

Size (nt)

Size (CDS)

Remarkable features of genomic region

Region 1

3,926,747

10,253

10,564

11

Type I restriction/modification system; DNA-invertase

Region 2

292,287

354,501

62,215

62

ICEEa1; metal resistance, hemin receptor precursor; mercury resistance; enterobactin exporter

Region 3

599,595

606,529

6,935

5

Tetratricopeptide repeat protein

Region 4

1,200,465

1,219,016

18,552

13

CTP pyrophosphohydrolase

Region 5

214,2546

216,0415

17,870

17

Putative polysaccharide synthesis clusters (capsule and LPS)

Region 6

217,9815

219,3156

13,342

13

Putative polysaccharide synthesis clusters (capsule and LPS)

Region 7

2,367,659

2,378,760

11,102

8

Putative deoxyribonuclease RhsC

Region 8

2,705,573

2,710,635

5,063

5

Glycosyl hydrolase, beta-glycosidase and beta-glucosidase

Region 9

2,898,750

2,904,987

6,238

5

Xylulose kinase, xylose isomerase, sodium/glucose co-transporter

Region 10

3,097,180

3,118,179

21,000

21

Transposase; FAD-dependent urate hydroxylase (flavoprotein involved in urate degradation to allantoin)

Region 11

3,477,609

3,483,251

5,643

7

Hypothetical proteins

Region 12

3,506,671

3,521,185

14,515

10

Starch-binding outer membrane protein; Ferrienterobactin receptor precursor; Susd/RagB outer membrane lipoprotein; Nisin biosynthesis protein NisC; Putative lantibiotic biosynthesis protein

Region 13

3,727,334

3,744,334

17,001

15

Transposase, IS200-like

Deletion†

3,779,205

3,856,342

77,138

75

Multidrug resistance protein MdtE and efflux pump membrane transporter BepE; HopJ type III effector protein (found in plant pathogens); ABC-2 family transporter protein; Cytochrome c551 peroxidase precursor; H(+)/Cl(−) exchange transporter ClcA; Sulfite exporter TauE/SafE; Bicarbonate transporter BicA; Vitamin B12 transporter BtuB precursor; Putative transporter YycB; beta-lactamase

  1. CTP, cytidine triphosphate; FAD, flavin adenine dinucleotide; LPS, lipopolysaccharide.
  2. Positions refer to the genome of reference strain CSID 3015183678.
  3. *Present in at least 90% of outbreak genomes and in <20% of the other E. anophelis.
  4. †Absent in four E. anophelis outbreak genomes (patient 30).
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