Figure 6: Association of elemental concentrations with measures of autism traits and clinical severity.

(a) Correlation of manganese, lead and zinc with Social Responsiveness Scale-2 (SRS-2) at different developmental time points. (b) The correlation of these elements with Autism Diagnostic Observation Schedule-2 (ADOS-2). Data are shown as 95% bands unadjusted (grey band) and adjusted (blue band) for intra-twin correlations. Grey vertical lines are Holm–Bonferroni corrected family-wise 95% CIs for 11 comparisons (every fifth week). Values above zero represent positive correlation between metal uptake and clinical index score. A critical window is defined as an area of the intra-twin adjusted correlation (blue band) that does not include zero. Models are adjusted for gender, gestational age and birth weight.