Figure 1: MicroRNA changes after 8 weeks of AD treatment. | Nature Communications

Figure 1: MicroRNA changes after 8 weeks of AD treatment.

From: MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes

Figure 1

(a) Experimental design. Discovery cohort (DRCT), baseline (T0), 8 weeks of treatment (T8), responders (RES) and nonresponders (NRES), *Number of significant miRNAs. (b) Venn diagram showing specific and commonly dysregulated miRNAs in duloxetine and placebo responders. (c) Correlation between miRNAs measured by small RNA-sequencing and a high-sensitivity multiplex cellular miRNA assay on a standard flow cytometer (Firefly BioWorks). (d) Small RNA Sequencing expression (number of reads per million, Log2) of miR-146a-5p, miR-146b-5p, miR-24-3p, miR-425-3p and miR-3074-5p after 8 weeks in MDD patients who responded to duloxetine treatment. ***FDR corrected P<0.001. (e) Scatterplots of Pearson’s correlations between differentially expressed miRNAs in blood samples from the discovery cohort. ***P<0.001.

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