Figure 3: Expression of miR-146a-5p, miR-146b-5p, miR-24-3p and miR-425-3p in an animal model of MDD and post-mortem human brain samples. | Nature Communications

Figure 3: Expression of miR-146a-5p, miR-146b-5p, miR-24-3p and miR-425-3p in an animal model of MDD and post-mortem human brain samples.

From: MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes

Figure 3

(a) Experimental design. Mouse model of MDD. Baseline (d0), 14 days of treatment (d14), responders (RES), nonresponders (NRES), susceptible (Susc) and Control (Ctrl). *Number of significant miRNAs. **Mice were treated with imipramine or saline solution. Resilient mice were not studied. (b) Differential expression of miR-146a-5p, miR-146b-5p, miR-24-3p and miR-425-3p after 14 days of imipramine treatment in mice by NanoString nCounter Digital Analyzer. *P<0.05; **P<0.01; ‡P<0.1. (c) Quantitative real-time PCR (qRT-PCR) expression data of miR-146a-5p, miR-146b-5p, miR-24-3p and miR-425-3p in vPFC of post-mortem brains of subjects with MDD and controls. *P<0.05; **P<0.01.

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