Figure 5: MicroRNA dysregulation of MAPK and Wnt signalling pathways. | Nature Communications

Figure 5: MicroRNA dysregulation of MAPK and Wnt signalling pathways.

From: MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes

Figure 5

(a) Expression of miR-146a-5p, miR-146b-5p, miR-24-3p and miR-425-3p in human NPCs treated with duloxetine or a no-drug control for 2 weeks (chronic treatment). *P<0.05. (b) Expression of MAPK/Wnt target genes in human NPCs treated with duloxetine or a no-drug control for 2 weeks (chronic treatment). *P<0.05; **P<0.01; ***P<0.001; ‡P<0.1. (c) Overexpression of miRNAs using miRNA mimics on human embryonic kidney cells (HEK293). (d) Heatmap showing P values of MAPK/Wnt target genes after overexpression of miRNAs in HEK293 cells.

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