Figure 4: Transcriptional patterns defining malignant and benign thyroid tissues.
From: The genetic landscape of benign thyroid nodules revealed by whole exome and transcriptome sequencing
(a) Venn diagrams showing overlaps between PTC-effective and benign nodule-effective genes. T versus N: PTC versus normal tissues (FC>1.5); B versus N: benign nodules versus normal tissues; (b) Overlap of PTC-effective genes (T versus N) with genes differentially expressed between PTC tumour and benign nodules (T versus B). (c) Unsupervised hierarchical clustering of transcribed genes (FPKM>1) and differentially expressed over 1.5-fold for 26 tissue samples. (d) TDS and ERK-activity score. Samples were coloured by tissue types (upper panel). The TDS was based on the expression of 16 genes and the ERK activation by the expression of 52 genes. The asterisk indicates the PTC samples with BRAFV600E mutation, and the key mutations in benign nodules were labelled.
