Figure 5: Phylogenetic analysis of individual patients demonstrates independent sample origins.
From: The genetic landscape of benign thyroid nodules revealed by whole exome and transcriptome sequencing
Two representative trees show examples of unrelated (PA15) and distantly related (PA8). (a,b) H&E staining of sampled thyroid tissues from patient PA15 (a) and PA8 (b). The left panel provides a histological view of the entire sample (bar, 1 cm) with the sampling region indicated by red box. Enlarged views of the sampled regions are shown in the right panels (bar, 200μm). (c,d) Phylogenetic trees based on mutation observed in PTC tumour, benign nodule(s) and normal tissue. The length of each line is proportional to the quantity of somatic mutations. The number of mutated genes is indicated near the line, and genes with key non-synonymous mutations were listed.
