Figure 4: POP2 tempers the in vivo inflammatory cytokine response.
From: Pyrin-only protein 2 limits inflammation but improves protection against bacteria
(a) Mean serum levels±s.d. of IL-1β, IL-18, TNF, IL-6, IL-12p40, IL-12p70, MCP-1 and IL-10 in POP2 (n=4) and LMC (n=4) mice receiving a sublethal dose (15 mg kg−1) of LPS for 24 h by i.p. injection. To determine significance, Student’s t-test was used. (b) Survival of POP2 Tg (n=14) and LMC (n=14) mice after i.p. injection with a lethal dose (50 mg kg−1) of LPS. Data represent per cent of surviving mice from at least two independent experiments. To determine significance, Log-rank test was used. *P<0.05, **P<0.01, ***P<0.001.
