Figure 1: TRPA1 is required for the antinociceptive effects of APAP. | Nature Communications

Figure 1: TRPA1 is required for the antinociceptive effects of APAP.

From: TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ9-tetrahydrocannabiorcol

Figure 1

Subcutaneous injections of APAP 1 h before nociceptive tests (300 mg kg−1, red bars; vehicle in black bars) significantly increased the paw-withdrawal latency in the hot-plate test (a) and reduced the number of writhes in the acetic-acid writhing test (b) in Trpa1+/+ mice, but not in their Trpa1−/− littermates. Effect of intraplantar injections of APAP (vehicle in black, 100 μg in red and 500 μg in blue) on C57BL/6J mice behavioural responses in the hot-plate (c) and paw-pressure (d) tests. Effect of intrathecal injections of APAP (50 μg in e and 100 μg in f) in the hot-plate test in Trpa1+/+ (empty circles) and Trpa1−/− mice (filled circles). Data show mean±s.e.m. for 6 mice per group. *P<0.05; **P<0.01 compared with vehicle group. ***P<0.001 compared with pre-injection latency. All data analysed by ANOVA followed by Tukey's HSD test.

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