Figure 5: APAP and its electrophilic metabolites are antinociceptive in the paw-pressure and cold-plate tests. | Nature Communications

Figure 5: APAP and its electrophilic metabolites are antinociceptive in the paw-pressure and cold-plate tests.

From: TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ9-tetrahydrocannabiorcol

Figure 5

APAP (300 mg kg−1, injected s.c. 1 h before tests) increased the paw-withdrawal threshold in the paw-pressure test (a) and paw-withdrawal latency in the cold-plate test (b) in C57BL/6J mice (vehicle in black, APAP in red). Dose-dependent effects of intrathecal injections of NAPQI (c,d; vehicle in black, 70 pg in red, 700 pg in blue and 7 ng in cyan) and p-BQ (e,f; vehicle in black, 250 pg in red, 25 ng in blue and 2.5 μg in cyan) in the paw-pressure test (c,e) and in the cold-plate test (d,f) in lightly restrained C57BL/6J mice. Data show mean±s.e.m. for 6 mice per group. *P<0.05; **P<0.01; ***P<0.001 compared with time-matched vehicle group (ANOVA followed by Tukey's HSD test).

Back to article page