Figure 6: Magnetic enhancement of vascular permeability in vivo.
From: Magnetic forces enable controlled drug delivery by disrupting endothelial cell-cell junctions
Athymic nude mice were injected with 33 nm MNPs through one later tail vein and the one on the opposite site was exposed to the magnetic treatment. After that, the mice were injected with ICG (ex/em=710 nm/810 nm). (a) Distribution of ICG without and with the magnetic treatment. The mice subjected to the magnetic treatment showed enhanced ICG accumulation in the area adjacent to the magnet. Scale bar, 10 mm. (b) Quantification of ICG accumulation based on fluorescence intensity (mean±s.d.; n=3; *P<0.05).
