Figure 1: DNAM-1 expression is dependent on MHC-I expression.
From: Expression of CD226 is associated to but not required for NK cell education
(a–c) DNAM-1 expression on B6 wild type versus B2m−/− mice. (a) Representative histograms of DNAM-1 expression on B6 (black line), B2m−/− (dotted line) or FMO control (shaded grey). (b) Compilation of frequency of DNAM-1+ NK cells and (c) compilation of DNAM-1 MFI on NK cells displayed as per cent of expression compared to B6 wild-type control. b,c represent five experiments with at least 2 mice per experiment and at least 13 mice in total. (d,e) DNAM-1 expression on mice with different MHC-I alleles. (d) Compilation of frequency of DNAM-1+ NK cells and (e) compilation of DNAM-1 MFI on NK cells displayed as per cent expression compared to B6 wild-type control, both of three experiments with at least two mice per group and experiment. Significant differences are calculated by unpaired t-test (b,c) or one-way ANOVA (d,e), and are depicted as *P<0.05, **P<0.01, ***P<0.001. Error bars denote s.d.
