Figure 5: DNAM-1 is not required for missing self recognition.
From: Expression of CD226 is associated to but not required for NK cell education
The ability of NK cells to kill MHC-I-deficient tumour targets correlates with DNAM-1 expression. (a–d) In vitro cytotoxicity of sorted DNAM-1+NKG2A+ (squares), DNAM-1+NKG2A− (circles) and DNAM-1−NKG2A− (triangles) IL-2-stimulated NK cells. (a) Killing of RMA, one representative of three experiments shown. (b) Killing of RMA-S, one representative of three experiments shown. (c) Calculation of the differential killing (±s.d.) between RMA-S and RMA killing, n=3 experiments. (d) Killing of YAC-1 n=3 experiments. (e,f) In vitro cytotoxicity towards RMA (circles) and RMA-S (squares) by IL-2-stimulated CD226−/− NK cells. (e) Shows one representative experiment of three and (f) shows differential killing between RMA-S and RMA, n=3 experiments. Error bars denote s.d.
