Figure 9: DNAM-1 expression changes after transfer to an MHC-I-different environment.
From: Expression of CD226 is associated to but not required for NK cell education
Expression of DNAM-1 changes after adoptive transfer from B6 to B6 (n=8) or B2m−/− (n=9) mice or from B2m−/− to B2m−/− (n=7) or MHC-I+ RAGcγ (n=8) mice. (a) Mature spleen NK cells were transferred as previously described36 (b) DNAM-1 frequency and (c) DNAM-1 MFI on NK cells after adoptive transfer. NK cells from transferred mice are gated on CD45.1+NK1.1+CD3− cells. Data are pooled from three independent experiments. P values are calculated using t-test for frequencies or Mann–Whitney test for MFI and are depicted *P<0.05, ***P<0.001. Error bars denote s.d.
