Figure 6: Transcription downregulation is ATM dependent. | Nature Communications

Figure 6: Transcription downregulation is ATM dependent.

From: A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks

Figure 6

(a,b) Coverage profile plot representing the RPM of transcripts of genes with AsiSI sites cut according to BLISS in induced (blue) and uninduced (red) samples in DMSO (a) or ATMi (b) treated cells. TES, transcription end site; TSS, transcription start site. Bold lines represent mean values, whereas semi-transparent shades around the mean curves represent the s.e.m. across the regions. (c) qPCR validation of relative expression of eight randomly selected genes in induced (blue) versus uninduced (red) samples upon DMSO (bars with texture) or ATMi treatment. Shown is the mean of biological replicates (n=3). Error bars show s.e.m.

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