Figure 2: Assessment of multi-regional sample clustering using primary and matched metastatic tissue. | Nature Communications

Figure 2: Assessment of multi-regional sample clustering using primary and matched metastatic tissue.

From: Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification

Figure 2

(a–g). Hierarchical clustering of our extended patient cohort, including CT, IF and LN tumour tissue, based on semi-supervised expression profiles of genes from the previously published 30 gene signature (a) and each individual independent gene signature, namely the stem-like (CMS4) (b), Jorissen (c), Eschrich (d), Sadanandam (CMS) (e), Kennedy (f) and Popovici (g) signatures. Top overlay bar represents colour coded patient-of -origin, labelled A–Y, with the bottom overlay bar representing region-of-origin, CT, green; IF, blue; LN, white.

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