Figure 3: A higher proportion of epithelial transcripts enables concordant clustering of patient tumour samples regardless of region-of-origin. | Nature Communications

Figure 3: A higher proportion of epithelial transcripts enables concordant clustering of patient tumour samples regardless of region-of-origin.

From: Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification

Figure 3

(a) Dot plots using normalized Pearson similarity scores for each individual gene expression signature as indicated. Error bars on dot plots represent s.d. values, with median bar. The colour label key for each signature is indicated on the right of this plot. (b) Median expression of all probesets annotated to the genes according to the cell-specific source of the transcripts in the 30 gene, stem-like (CMS4), Jorissen, Eschrich, Sadanandam (CMS) and Kennedy signatures using epithelial, fibroblast, endothelial, and leukocyte populations isolated by FACS (GSE39396). (c) Median expression of all probesets annotated to the genes according to the cell-specific source of the transcripts in the Popovici signature using epithelial, fibroblast, endothelial, and leukocyte populations isolated by FACS (GSE39396).

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