Figure 5: Assessment of multi-region sample clustering into concordant subtypes and into individual patient clusters. | Nature Communications

Figure 5: Assessment of multi-region sample clustering into concordant subtypes and into individual patient clusters.

From: Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification

Figure 5

(a) Dot plots using normalized Pearson similarity scores for each individual gene expression signature (as in Fig. 3a) now including the CRIS signature. Error bars on dot plots represent s.d. values, with median bar. (b) Patient group overall ratio plot demonstrating the ability of each individual signature to concordantly cluster patient samples as an indication of confounding transcriptional ITH. For example, the 30 gene signature displays an immediate drop in concordant sample clustering, indicating high levels of confounding transcriptional ITH. The CRIS signature maintains a high level of concordant clustering at both the initial subtype, (left of x axis), and continues to cluster samples according to each individual patient, (right of x axis). The proportion of patients with all samples in the same cluster is measured on the y axis from 1 to 0, relative to the number of clusters on the x axis from 2 to 24. Each continuous signature score is colour coded as outlined in the legend and in the colour label key.

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