Figure 3: Vital signs and clinical status of macaques before and after ZIKV infection.

(a) Weight expressed in kilograms (kg). (b) Corporal temperature (in Celsius) measured using an infrared device. (c) Rectal temperature (in Celsius) was also measured. (d–g) Cell subsets: white blood cell (WBC), lymphocyte (LYM), neutrophil (NEU) and monocyte (MON) kinetics obtained from complete blood cell (CBC) counts (10⁶ cells per ml) at baseline and on days 7 and 15 p.i. in absolute numbers. Comparison of absolute NEU numbers within cohorts at day 7 related to their own baseline values was performed using a two-tailed unpaired t-test with Sidak–Bonferroni correction (P<0.01). (h–j) Levels of platelets (10⁶ PLT per ml), Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) at baseline, 7 and 15 d.p.i. In all panels, the DENV-1 immune macaques are in blue, DENV-2 immune ones in magenta, and naïve ones in black.