Figure 4: DENV-immune serum cross-reacts with ZIKV.
From: Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus
(a) Binding of baseline samples from the naïve (black circles) and the DENV-immune macaques (blue and magenta symbols for DENV-1 and DENV-2 immune macaques, respectively) assayed in six concentrations of serum and expressed as OD values at 492 nm. (b) Binding of samples collected 30 d.p.i. is represented as in a. In the first two-endpoints, serum from previous immunity to DENV resulted in significantly higher OD values (P<0.01 and P<0.05). Data are representative of duplicate samples per concentration in one experiment. Comparison of ZIKV IgG titres, expressed as OD values, within cohorts related to their own baseline values was performed using a two-tailed unpaired t-test with Sidak–Bonferroni correction (*P<0.05).
