Figure 8: Previous exposure to DENV modulates the cytokine and chemokine profiles after ZIKV infection.
From: Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus
(a–h) Profiles of marked cytokines and chemokines after ZIKV infection of DENV-immune and naïve cohorts are depicted logarithmically in pg ml−1. Mean values are shown in orange and black lines for DENV-immune and naïve cohorts, respectively. Comparison of the levels of cytokines and chemokines within cohorts related to their own baseline values or among cohorts was performed using a two-tailed unpaired t-test with Sidak–Bonferroni correction. Black circles represent individual naïve macaques, and blue and magenta squares represent macaques previously exposed to either DENV-1 or DENV-2, respectively. Dotted lines indicate the threshold of detection for each assay.
