Figure 4: Single-cell GPCR expression in different EC types. | Nature Communications

Figure 4: Single-cell GPCR expression in different EC types.

From: Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system

Figure 4

(a) Heat map of GPCR expression in EClu, ECsk, ECbr (48, 40, 52 cells per EC type, from six to eight mice per group); horizontal bars on the right side visualize expression frequency in % (for full data sets, Supplementary Fig. 6). (b) Average number of GPCRs expressed in individual EC types (mean±s.e.m.). (c) T-SNE plot of k-means clustering data for different EC types: cluster assignment is indicated by coloured numbers, cell type is indicated by symbol (each dot one cell; distance between dots indicates degree of similarity). (d–f) Genes differentially expressed in cluster 1 (EClu, d), cluster 2 (mainly ECsk, e), and cluster 3 (mainly ECbr, f) (only genes significantly regulated (P>0.05) and with fold change <0.7 or >1.5 are displayed). Data in b are mean±s.e.m.

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