Figure 3: Adipocyte MHCII deficiency attenuates adipose inflammation. | Nature Communications

Figure 3: Adipocyte MHCII deficiency attenuates adipose inflammation.

From: Adipocyte adaptive immunity mediates diet-induced adipose inflammation and insulin resistance by decreasing adipose Treg cells

Figure 3

Gene expression profiles in a adipocytes (b) CD3+ ARTs and (c) ATMs isolated from epididymal adipose tissue at of WT and aMHCII−/− (KO) mice at 12 weeks HFD (N=3–4 per group). Flow cytometry analysis of epididymal adipose tissue (d) ART and ATM, (e) CD4+ and CD8+ ART, and (f) CD4+ Treg and Tconv abundance and (g) Treg and (h) ST2+ Treg prevalence (N=3 per group). (i) Adipose tissue IL-33 expression (N=5 per group). Flow cytometry analysis of (j) CD11c, (k) CD206 and (l) CD36 in ATMs from HFD-fed WT and KO mice. Ma: Metabolically activated macrophage. Mean±s.e.m.; *P<0.05 or +P<0.1 versus WT by t-test.

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