Figure 6: Adipocyte MHCII can regulate HFD-induced adipose inflammation via IFNγ. | Nature Communications

Figure 6: Adipocyte MHCII can regulate HFD-induced adipose inflammation via IFNγ.

From: Adipocyte adaptive immunity mediates diet-induced adipose inflammation and insulin resistance by decreasing adipose Treg cells

Figure 6

(a) Adipose tissue of chow-fed lean mice is characterized by low-level adipocyte MHCII expression and anti-inflammatory balance of Treg+Th2 to Th1 ARTs and M2 to M1+metabolically-activated (Mme) ATMs. (b) HFD-induced obesity robustly increases Th1 IFNγ that can (1) increase adipocyte MHCII to further promote Th1 activation and (2) inhibit adipose Treg ST2 expression to reduce IL-33-driven proliferation to directly and indirectly stimulate M1 and Mme ATM polarization. (c) HFD-fed aMHCII KO mice demonstrate attenuated ART IFNγ expression, with reductions in all these pro-inflammatory phenotypes.

Back to article page