Figure 10: Schematic model of CoMIC for mitochondrial division.
From: Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division
Intra-mitochondrial Ca2+ flux triggers mitoBKCa-mediated mitochondrial bulging and depolarization. Synergistically, stabilized Oma1 cleaves L-Opa1 resulting accumulation of S-Opa1, which neutralizes Mic60-mediated OMM–IBM tethering. This CoMIC contributes to Drp1-mediated mitochondrial division.
