Figure 5: Synthesis of [18F](R)-1 via an iodonium ylide precursor. | Nature Communications

Figure 5: Synthesis of [18F](R)-1 via an iodonium ylide precursor.

From: Synthesis and preliminary PET imaging of 11C and 18F isotopologues of the ROS1/ALK inhibitor lorlatinib

Figure 5

Reagents and conditions: (a) 2 mg iodonium ylide (R )-13 in 400 μl of DMF (anhydrous), azeotropically dried [18F]Et4NF, 80 °C, 10 min.; (b) HPLC purification followed by C18 SPE isolation; (c) 4 M HCl, 90 °C, 10 min; (d) neutralization to pH 5 using NaOH and NaOAc, reformulation on HLB SPE.

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