Figure 6: ILC2 derived IL-5 and IL-13 are required to reduce atherosclerosis.

Ldlr^−/− recipients of mixed bone marrow transplants of ILC2^WT, ILC2^KO, 80% ILC2^KO with 20% IL-5⁺ or 80% ILC2^KO with 20% IL-5^KO, 80% ILC2^KO with 20% IL-13⁺ 80% ILC2^KO with 20% IL-13⁻ were maintained on HFD for 8 weeks. Atherosclerosis in the aortic arch was quantified after Oil Red O staining, multiple comparison using Kruskal–Wallis yielded a P value of 0.03 (a). Representative images and quantification of atherosclerotic lesion size in aortic sinus of ILC2^KO IL-13⁻ and ILC2^KO IL-13⁺ recipients (b). Proportional and numerical decrease of Arg1⁺ cells in aortic sinus of ILC2^KO IL-13⁻ recipients (c). Reduced collagen deposition in lesions of ILC2^KO IL-13⁻ recipients (d). Graph data points represent individual mice and statistical significance was determined by Mann–Whitney U-test or two-way ANOVA where appropriate. Scale bars: 270 μm.