Figure 1: Schematic view of antibody epitopes and ERβ isoforms.
From: Insufficient antibody validation challenges oestrogen receptor beta research
Overview of ERβ isoforms and regions targeted by ERβ antibodies included in the study. PPZ0506, 14C8 and PPG5/10 are indicated in bold. The structural domains of the ERβ protein (A,B: amino-terminal and activating function AF-1 domain, C: DNA-binding domain, D: hinge region (with nuclear localization and dimerization binding), E: ligand-binding domain and AF-2, and F: carboxyterminal end).
