Figure 5: Compilation of ERβ expression data in breast.
From: Insufficient antibody validation challenges oestrogen receptor beta research
(a) ERα and ERβ protein expression determined using IHC in 17 different studies. The total percentages of ERα- and/or ERβ-positive BC cases are shown. The ERβ antibody used in each study is indicated below. (b) RSEM expression estimates of ERα (ESR1) and ERβ (ESR2) mRNA expression in TCGA’s BRCA cohort, including 99 normal breast specimens, 995 breast tumours, and 7 distant metastases. For the ERα-expression graph (left), the tumour samples are divided into ERα-positive and ERα-negative status based on clinical pathology diagnosis. For ERβ (right panel) samples are divided into normal, tumour and metastatic samples. The violin plots show probability densities for the expression in the indicated subsets of the cohort, with the medians indicated by black crossbars.
