Figure 8: Clinical relevance of miR-128-3p with activation of β-catenin and TGF-β signalling, and expression levels of its target genes and pro-EMT/pro-metastatic markers. | Nature Communications

Figure 8: Clinical relevance of miR-128-3p with activation of β-catenin and TGF-β signalling, and expression levels of its target genes and pro-EMT/pro-metastatic markers.

From: Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC

Figure 8

(a) miR-128-3p expression levels correlate with localization of β-catenin and SMAD3, as well as expression of its target genes, including Axin1, SFRP2, WIF1, SMURF2 and PP1c, two key EMT markers (E-cadherin and Vimentin) and the endothelial marker CD34. Two representative cases (Low and High miR-128-3p) are shown. Scale bar, 25 μm. (b) Percentage of specimens showing cytoplasmic/nuclear or membrane β-catenin, nuclear or cytoplasmic SMAD3, low- or high expression of E-cadherin, Vimentin, Axin1, SFRP2, WIF1, SMURF2 or PP1c and CD34 intensity in patient specimens, respectively, with low and high miR-128-3p expression. (c) Model for miR-128-3p-mediated tumorigenesis, metastasis and chemoresistance in NSCLC.

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