Table 1 Univariate and multivariate Cox regression analyses of OS and RFS in OSCC patients.

From: Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression

Covariates

Univariate analysis

Multivariate analysis

 

HR (95% CI)

P -value

HR (95% CI)

P -value

OS

 Age (≤50 versus >50 years)

2.299 (0.872–6.062)

0.092

1.860 (0.580–5.965)

0.296

 T status (≤4 cm versus >4 cm)

2.820 (1.137–6.991)

0.025*

2.417 (0.584–9.991)

0.222

 Stage (I+II versus III+IV)

3.221 (1.156–8.979)

0.025*

1.045 (0.164–6.636)

0.962

 Tumour differentiation (G1 versus G2+G3)

2.556 (1.034–6.319)

0.042*

1.547 (0.517–4.628)

0.434

 Lymph node metastasis (N0 versus N1–3)

3.222 (1.259–8.239)

0.014*

3.193 (0.845–12.058)

0.086

 LncHIFCAR expression level (high versus low)

2.701 (1.058–6.896)

0.037*

2.239 (0.719–6.966)

0.163

RFS

 Age (≤50 versus >50 years)

1.575 (0.713–3.479)

0.261

0.967 (0.315–2.967)

0.954

 T status (≤4 cm versus >4 cm)

1.569 (0.697–3.526)

0.276

1.827 (0.457–7.299)

0.394

 Stage (I+II versus III+IV)

1.986 (0.897–4.394)

0.090

0.602 (0.083–4.339)

0.615

 Tumour differentiation (G1 versus G2+G3)

2.709 (1.242–5.909)

0.012*

1.453 (0.608–3.469)

0.401

 Lymph node metastasis (N0 versus N1–3)

3.043 (1.374–6.735)

0.006**

4.147 (0.869–19.770)

0.074

 LncHIFCAR expression level (high versus low)

3.686 (1.616–8.409)

0.002**

3.500 (1.317–9.302)

0.012*

  1. CI, confidence interval; G1, well-differentiated; G2, moderately differentiated; G3, poorly differentiated; HR, hazard ratio; OS, overall survival; OSCC, oral squamous cell carcinoma; RFS, recurrence-free survival.
  2. Statistically significant (*P<0.05 and **P<0.01).
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