Table 1 IC50 values of anthracyclines for cancer cell lines in normoxia or hypoxia.

From: Hypoxia-induced mobilization of NHE6 to the plasma membrane triggers endosome hyperacidification and chemoresistance

Cell line

MDA-MB-231

HT-1080

Treatment

21% O 2

1% O 2

Fold change

P- value

21% O 2

1% O 2

Fold change

P- value

Dox

125.3±2.7

688.1±28.4

5.5

<0.0001

73.4±3.9

301.2±30.9

4.1

<0.0001

Mtx

151.7±9.4

752.2±37.5

5.0

<0.0001

93.5±7.6

451.2±23.8

4.9

<0.0001

Dau

198.8±4.8

921.3±69.3

4.7

0.029

101.9±30.5

813.8±29.3

8.1

<0.0001

  1. Dau, daunorubicin; Dox, doxorubicin; Mtx, mitoxantrone; IC50, half-maximal inhibitory concentration.
  2. Data are presented as the mean (nM)±standard deviation. Fold change was calculated as the drug IC50 of cells exposed to 1% O2 to the IC50 of cells exposed to 21% O2. n=3–5 independent experiments with three replicates in each experiment. P values were determined using unpaired t-test with Welch correction.
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