Figure 3: Trifluoroethylation reactions of secondary amines.
From: A practical and catalyst-free trifluoroethylation reaction of amines using trifluoroacetic acid
Isolated yields following chromatography. aIsolated as its HCl salt following aqueous work up. bProduct is volatile. cThe reaction was quenched with 1 M NaOH to desilylate the hydroxyl group (THF, tetrahydrofuran; TBS, tert-butyldimethylsilyl).
