Figure 1: Differential alternative splicing events in AA PCa compared with EA PCa and AA NP compared with EA NP specimens. | Nature Communications

Figure 1: Differential alternative splicing events in AA PCa compared with EA PCa and AA NP compared with EA NP specimens.

From: Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer

Figure 1

(a) Principal component analysis (PCA) plot and two-dimensional (2D) clustergram depicting 3,112 significant differentially expressed exons in 20 independent AA PCa versus 15 independent EA PCa specimens. (b) PCA plot and 2D clustergram depicting 3,384 significant differentially expressed exons in 20 AA NP versus 15 EA NP specimens. AA and EA specimens are represented by red and blue circles/bars, respectively. Rows represent specimens and columns represent exons in hierarchical clustergrams. Log2 expression values of exons were subjected to 2D unsupervised hierarchical clustering using average linkage method and Euclidean distance. (c) Venn diagrams of DS events in AA PCa versus EA PCa and AA NP versus EA NP, DS events in EA PCa versus EA NP and AA PCa versus AA NP and differentially expressed genes in AA PCa versus EA PCa and DS events in AA PCa versus EA PCa. (d) A majority of the genes with DS events in AA PCa versus EA PCa were functionally associated with cancer. The top three ‘other diseases’ were gastrointestinal disease, organismal injury and abnormalities and reproductive system disease.

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