Table 2 Copy number of putative target genes in areas of chromothripsis amplification.

From: Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma

Chr â–¸

5

12

17

Gene â–¸

TERT

RICTOR

CCND2

MDM2

CDK4

TP53

COPS3

NF1

Sample â–¼

        

PD13486a

−

+3

      

PD7190a

+1

+6

      

PD9962a

+5

+2

      

PD13490a

+4

+7

   

LOH

+13

BP

PD13478a

  

+1

+20

+22

   

PD13495a

  

+1

+5

−

   

PD7401a

  

+6

+10

+8

   

PD7508a

  

+2

+17

+23

   

PD13492a

  

+1

−

+15

LOH+BP

+16

−

PD13476a

     

LOH+BP

+16

LOH

PD7513a

     

LOH+BP

+25

LOH

PD9056a

     

LOH+BP

+26

−

  1. BP, breakpoint present within gene footprint; Chr, chromosome; LOH, loss of heterozygosity.
  2. Allele-specific copy number of putative target genes in regions with chromothripsis amplification. For oncogenes (TERT, RICTOR, CCND2, MDM2, CDK4, COPS3) copy number gain of the major allele is shown. For tumour suppressor genes (TP53, NF1) the minor allele is shown. Numbers preceded by ‘+’ indicate number of extra copies. The bold cells indicate significant copy number gain, the italicized cells indicate significant copy number loss.
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