Figure 2: Clinical validation of nCD64 for sepsis stratification and prognostication. | Nature Communications

Figure 2: Clinical validation of nCD64 for sepsis stratification and prognostication.

From: A point-of-care microfluidic biochip for quantification of CD64 expression from whole blood for sepsis stratification

Figure 2

(a) The CD64 expression histograms for monocytes, neutrophils and lymphocytes for n=450 blood samples. The inset histogram represents nCD64 expression for all the blood samples. (b) The plot represents the ratio of mCD64/ nCD64 versus nCD64. (c) ROC curves showing sepsis predictability using Quick SIRS (AUC=0.7) and SIRS + CD64 (AUC=0.77). (d) The box plots showing the control nCD64 expression value from 316 blood samples collected from 68 patients (who recovered later) at different time windows of their hospital stay. (e) The box plots showing the control nCD64 expression value from 94 blood samples collected from six patients who are at different times of their hospital stay. Unfortunately, these patients did not recover. (f) The nCD64 and WBC counts are used for sepsis prognosis for all the six time windows using ANN model. ROC curves for TW1 (left) and TW5 (right) show the highest AUC>0.9 for sepsis prognosis by predicting the recovery of the patients. P-values are reported in Methods section.

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