Figure 3: Regional association plots and expression of the novel DTC-associated variant. | Nature Communications

Figure 3: Regional association plots and expression of the novel DTC-associated variant.

From: Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer

Figure 3

A regional association plot for the (a) VAV3, (b) PCNXL2, (c) FHIT, (d) SEPT11, (e) MSRB3 and (f) INSR regions. The large purple diamonds indicate the most associated SNPs according to joint analyses and nearby SNPs are colour coded according to the level of LD with the top SNP. The left y-axis shows the significance of the association on a −log10 P-value (logistic regression), and the right y-axis shows the recombination rate across the region. Estimated recombination rates from the 1,000 Genomes ASN, hg19 database are plotted by the blue line to reflect the local LD structure. The cis-eQTL results of (g) VAV3 and (h) PCNXL2 in tumour and normal thyroid tissues, and the predicted expression of 470 DTC cases according to the rs4915076 and rs4649295 genotypes, respectively (additive model of linear regression analyses, error bars represent s.e.m.).

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