Table 1 2D kinetic and equilibrium constants of ternary complex formation.

From: Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments

Interaction

(mol−1 mm2 s−1)*

(s−1)*

(molecules μm−2)

IL-4/IL-4Rα ↔ IL-13Rα1

(3.8±1.0)·1015

0.23±0.04

36±15*

1.6±0.4†

0.1±0.1‡

IL-13/IL-13Rα1 ↔ IL-4Rα

(1.1±0.6)·1014

0.0023±0.0007

13±11*

n.d.

0.4±0.2‡

KFR/IL-4Rα ↔ IL-13Rα1

—

<0.002

<5*

0.3±0.1†

0.4±0.2‡

RGA/IL-4Rα ↔ IL-13Rα1

—

>0.5

296±104*

(>5)

1.2±0.6‡

  1. *Molecular interactions determined with receptor ectodomains tethered onto SSMs.
  2. †Molecular interactions determined with transmembrane receptor reconstituted into PSMs.
  3. ‡Effective estimated from single molecule dimerization assays in the plasma membrane of living cells.
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