Figure 9: Model: ERG mediates Ang1 potentiation of Dll4/Notch signalling. | Nature Communications

Figure 9: Model: ERG mediates Ang1 potentiation of Dll4/Notch signalling.

From: The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability

Figure 9

(a) Notch-ERG positive feedback loop. ERG drives expression of the Notch ligand Dll4 and is required for endothelial Notch signalling. Notch signalling itself upregulates ERG expression, suggesting that continued Dll4 expression and Notch signalling is maintained through this positive feedback loop. (b) ERG is required for Ang1 induction of Dll4. In confluent cells, Ang1/Tie2 signalling induces PI3K/Akt-dependent ERG phosphorylation (P). This increases ERG binding to the Dll4 gene locus and recruitment of β-catenin. The complex of ERG with NICD and β-catenin mediates Ang1-dependent Dll4/ Notch signalling in confluent EC.

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