Figure 2: MetaXcan-predicted association of predicted gene transcript levels with grip strength across biologically relevant tissues in GTEx. | Nature Communications

Figure 2: MetaXcan-predicted association of predicted gene transcript levels with grip strength across biologically relevant tissues in GTEx.

From: Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

Figure 2

Data are shown for all genes at which altered transcription was significantly associated with grip strength in at least one biologically relevant tissue, after accounting for multiple testing. Data are z-scores of transcript level association with higher handgrip strength, clustered by tissue. Direction of z-score indicates whether higher or lower gene expression is associated with higher grip strength. Absolute z-score>1.96 indicates nominal significance at P≤0.05, and ≥4.94 indicates significance after adjustment for multiple testing (P≤7.91 × 10−7). NAcc, nucleus accumbens.

Back to article page