Figure 2: RGES is dependent on biological conditions.
From: Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets
(a) RGES of the top four most profiled compounds. Red dots represent drug signatures profiled in the cell lines that share the same lineage with the given cancer type. (b) s.d. of RGES of individual compounds across different cell lines versus across replicates within the same cell line. (c) RGES distribution between two treatment duration groups (<24 and ≥24 h). (d) RGES distribution between two drug concentration groups (<10 and ≥10 μM). Treatment and concentration groups were categorized based on the distribution of drug profiles in LINCS.
