Figure 4: DVL2 binding to FZD4 is dispensable for Norrin-induced endocytosis. | Nature Communications

Figure 4: DVL2 binding to FZD4 is dispensable for Norrin-induced endocytosis.

From: Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function

Figure 4

(a–c) FZD4 mutations that disrupt DVL2 binding fail to recruit DVL2 to the plasma membrane and block WNT5A/PMA-induced endocytosis. (d–f) Norrin-induced FZD4 endocytosis is not affected by FZD4 mutations that disrupt DVL2 binding. DVL2 was co-expressed in all a–f. Scale bar, 10 μm.

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