Figure 2: Locations of the bound K-80003 molecules and their interactions with RXRα-LBD. | Nature Communications

Figure 2: Locations of the bound K-80003 molecules and their interactions with RXRα-LBD.

From: Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα

Figure 2

(a) Superposition of a monomer subunit (green cartoon) with bound K-80003 molecules K-80003A (brown sticks) and K-80003C (blue/red sticks) on the agonist-binding RXRα-LBD (magenta cartoon, PDB code 1FBY, ligand 9-cis-RA in yellow/red stick). (b) Binding of the three K-80003 molecules (blue and brown sticks) at the interface between subunits A1 and B2 of the RXRα-LBD tetramer. Selected side-chains of RXRα-LBD subunits that interact with the ligands are shown as sticks.

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