Figure 8: Reactivation of anti-tumour Tcm cells is mediated by Batf3-dependent DCs. | Nature Communications

Figure 8: Reactivation of anti-tumour Tcm cells is mediated by Batf3-dependent DCs.

From: Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells

Figure 8

(a) For Tcm cell generation, WT and/or Batf3−/− mice were transferred with OT-I CD45.1+ T cells 1 day before i.d. infection with rVACV-OVA in the ear. After 30 days, OT-I CD45.1+ Tcm cells from donor mice were sorted and transferred to WT and/or Batf3−/− recipient mice. One day after transfer, mice were inoculated with B16-OVA cells (i.d.) in the flank. (b–d) B16-OVA growth curve plotted as tumour size (mm3) over time in the indicated recipient mice transferred with Tcm cells from the indicated donor mice. Pool of two independent experiments represented as tumour size mean±s.e.m. (b–d) (n=6–8 per group). NS, not significant, ***P<0.001; **P<0.01 by two-way ANOVA (b–d) with Bonferroni post-hoc test.

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