Figure 2: Comparative analysis of available ALDP-related biosynthetic gene clusters. | Nature Communications

Figure 2: Comparative analysis of available ALDP-related biosynthetic gene clusters.

From: 4-alkyl-L-(Dehydro)proline biosynthesis in actinobacteria involves N-terminal nucleophile-hydrolase activity of γ-glutamyltranspeptidase homolog for C-C bond cleavage

Figure 2

The genes coding for ALDP formation are coloured. ant, for anthramycin; por, for porothramycin; sib, for sibiromycin; tom, for tomaymycin; hrm, for hormaomycins and lmb, for lincomycin A. For sequence identities of deduced proteins, LmbA is homologous to Ant6 (72.3%), Por11 (72.9%), SibY (58.0%), TomL (50.0%) and HrmG (64.6%); LmbY is homologous to Ant14 (49.8%), Por15 (48.2%), SibT (53.5%), TomJ (50.2%) and HrmD (46.3%); LmbB1 is homologous to Ant12 (40.8%), Por13 (44.6%), SibV (54.4%), TomH (52.8%) and HrmF (46.2%); and LmbB2 is homologous to Ant13 (31.2%), Por14 (30.9%), SibU (38.7%), TomI (37.3%) and HrmE (42.9%).

Back to article page