Figure 2: Reactions and compounds studied in this work.
From: De novo active sites for resurrected Precambrian enzymes
(a) The Kemp elimination of 5-nitrobenzioxazole (5-nitro-benzo[d]isoxazole). A schematic transition state structure is shown here; (b) tryptophan; (c) 5(6)-nitrobenzotriazole (a transition-sate analogue) and (d) indole (the tryptophan side chain). Finally, (e) the hydrolysis of p-nitrophenyl acetate is also shown here.
