Table 3 Summary of steady-state inactivation measurements.

From: Perturbation of sodium channel structure by an inherited Long QT Syndrome mutation

Construct

V1/2

P -value versus WT

k

P -value versus WT

n

WT (Nav1.5)

−69.1±3.3

 

6.5±0.5

 

9

H4 (F1855H/K1859H)

−68.8±1.8

0.95

5.8±0.4

0.26

6

H6-N (H1900/V1903H)

−68.5±1.3

0.87

5.9±0.3

0.30

7

H6-M (M1906H/R1910H)

−66.5±1.1

0.48

6.1±0.4

0.43

8

H6-C (H1915/Q1918H)

−67.8±1.9

0.73

5.8±0.3

0.17

9

S1904L

−68.5±2.0

0.88

6.9±0.3

0.58

8

S1904L H6-N

−71.9±3.5

0.56

7.6±0.5

0.15

7

S1904L H6-M

−75.9±0.6

0.07

7.6±0.8

0.29

7

S1904L H6-C

−69.1±2.4

0.99

7.9±0.3*

0.03

8

  1. Voltages of steady-state inactivation (V1/2) and the slope (k) were calculated from the average of fits, using the Boltzmann function, to the experimental data from each cell. Values are reported as the mean±s.e.; n indicates the number of experiments.
  2. *Represents statistically significant (P<0.05) relative to WT.
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