Figure 2: Increase of UUE and the frequency of overproduction hyperuricemia by ABCG2 dysfunction.
From: Decreased extra-renal urate excretion is a common cause of hyperuricemia
(a) UUE according to each ABCG2 function (n=644). Patients with hyperuricemia were divided into four groups by their estimated ABCG2 functions, that is, full function, 3/4 function, 1/2 function and ≤1/4 function. UUE showed an inverse association with ABCG2 functions (P=3.60×10−10 by simple linear regression analysis). All bars show mean±s.e.m. (b) Frequency of 'overproduction' hyperuricemia according to each ABCG2 function. 'Overproduction' hyperuricemia consists of overproduction type and combined type.
