Figure 3: Urate excretion via Abcg2 in a mouse model.
From: Decreased extra-renal urate excretion is a common cause of hyperuricemia
(a) Concentration-dependent urate transport via Abcg2 (n=3). (b) Effect of oxonate on Abcg2-mediated urate transport (n=3). (c–e, g, h) In vivo study using Abcg2-knockout and wild-type mice. (c) Serum uric acid (SUA) levels (n=19–20). ***P=8.8×10−6. (d) Urinary excretion of urate (n=10–11). ***P=4.1×10−4 (e) Time course of intestinal urate excretion (n=4). ***P<0.001; **P=0.0066; *P=0.021. (f) Transintestinal urate transport (n=3–4). *P=0.037 and 0.034 for 20 min and 30 min, respectively. (g) Urate excretion in intestine and bile (n=3–4). ***P=3.6×10−4. All bars show means±s.e.m. P values were obtained by Student's t-test. NS, not significant. (h) Relative contribution of urinary, intestinal and biliary urate excretion pathways.
