Table 1 Relationship between overproduction hyperuricemia and ABCG2 dysfunction.

From: Decreased extra-renal urate excretion is a common cause of hyperuricemia

Estimated transport activity

Genotype

N

Frequency of OP hyper-uricemia

RR

95% CI

P

Adjusted RR†

Adjusted 95% CI†

Adjusted P†

 

Q126X (rs72552713)

Q141K (rs2231142)

OP hyper-uricemia*

Non-OP hyper-uricemia*

       

≤1/4 Function

X/X

Q/Q

26

3

0.897

2.35

1.86–2.97

3.32×10−7

2.30

1.31–3.90

2.65×10−3

Q/X

Q/K

         

1/2 Function

Q/X

Q/Q

96

55

0.636

1.66

1.32–2.10

8.58×10−6

1.79

1.25–2.59

1.55×10−3

Q/Q

K/K

         

3/4 Function

Q/Q

Q/K

160

147

0.521

1.36

1.09–1.71

4.55×10−3

1.42

1.03–2.00

0.035

Full function

Q/Q

Q/Q

60

97

0.382

1.00

     
  1. Abbreviations: CI, confidence interval; OP, overproduction; RR, risk ratio.
  2. *Patients were classified as OP hyperuricemia (OP type and combined type) when their UUE was over 25.0 mg h−1/1.73 m2 (600 mg per day/1.73 m2).
  3. UUE was normalized for a body surface area of 1.73 m2. Other patients were classified as non-OP hyperuricemia.
  4. †Using Poisson regression analysis, RR, 95% CI, and P value are adjusted with covariates of body mass index, alcohol intake, and single nucleotide polymorphisms of urate-related genes (rs506338 in URAT1, rs11722228 in GLUT9 and rs12129861 in PDZK1).
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